Cyclin K and cyclin D1b are oncogenic in myeloma cells
نویسندگان
چکیده
منابع مشابه
Cyclin D1b in human breast carcinoma and coexpression with cyclin D1a is associated with poor outcome.
BACKGROUND/AIM Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear export. Studies of murine fibroblasts have shown that although overexpression...
متن کاملAn alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.
Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary. Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers. Cyclin D1 (CCND1) undergoes alterna...
متن کاملKinase independent oncogenic cyclin D1
a driving force in breast cancer and many other types of human tumors. Cyclin D1 overexpression is found in up to 50% of human breast cancers, and the pattern of cyclin D1 overexpression in tissues along the spectrum from normal epithelium to invasive breast cancer suggests its involvement in the earliest stages of mammary carcinogenesis. The importance of cyclin D1 as a driver oncogene is rein...
متن کاملConsequence of the tumor-associated conversion to cyclin D1b
Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to cyclin D1b. Extensive analyses uncovered overlapping but non-redundant functions of cyclin D1b compared to cyclin D1 on developmental phenotyp...
متن کاملTitle page Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma
Background. The CCND1 gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of a common A/G polymorphism. Cyclin D1a and b proteins differ in their C-terminus, a region involved in protein degradation and sub-cellular localization. Recent data have suggested that cyclin D1b could be a nuclear oncogene. The presence of cyclin D1b mRNA and protein has been stud...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2010
ISSN: 1476-4598
DOI: 10.1186/1476-4598-9-103